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Understanding Esters and Their Differences
Trenbolone Acetate, Trenbolone Enanthate, Testosterone Cypionate, Testosterone Propionate ...
What do all these names mean? Does this have an influence on determining what products to use?
YES: the name of the ester is very important for devising your treatment.
One of the most misunderstood topics in the world of steroids is the ester : that is, the mechanism by which steroids such as testosterone cypionate and Testosterone enanthate, esterified injectables such as Sustanon or Trenbolone enanthate, or acetates work in your body.
If you take a look on the internet you will probably find countless articles that consider one form of steroid much more effective than another.
The arguments about the superiority of cypionate compared to enanthate or of Sustanon compared to all other testosterones are, of course, but very common misconceptions.
Indeed, each ester has its particular benefits and when intelligently used in your treatment, it will be your perfect ally to get the results you desire.
What is an Ester?
Take the example of testosterone, which comes in different esters: cypionate, enanthate, propionate, heptylate, caproate, phenylpropionate, isocaproate, decanoate, acetate ... the list goes on and on.
In all these examples, the hormone "mother" is testosterone, which has been modified by adding an ester to its structure.
The following question arises: What is the difference between "esterified" versions of testosterone in their use?
It is simply a matter of speed of assimilation of the molecule in the body.
In chemistry, the function ester denotes a characteristic group formed of an atom simultaneously bonded to an oxygen atom by a double bond.
This carbon chain is usually attached to the steroid hormone in a position referred to as beta orientation.
The esterification of Anabolic Steroids / Injectable androgens essentially accomplishes one thing: it slows the release of the active substance of the molecule from the injection site.
This happens because the ester will include reduced solubility in the water or oil containing the steroid.
This will form a deposit in the muscle tissue, from which the flow will slow and the steroid will be absorbed in small quantities by the blood.
Generally, the more soluble the chain of the ester is, the quicker the hormone is released.
The slower release of the hormone is a great advantage in a treatment. Indeed, without the added ester, free testosterone (or other steroid hormones) would remain active in the body for a very short period of time (usually a few hours). This would therefore require a heavy and unpleasant daily injection schedule if you wanted to maintain a high and stable level of testosterone in the body.
With the addition of an ester, the athlete can therefore reduce the frequency of injections.
The addition of an ester finally provides ease of use for users, making the therapy much less constraining.
Is any one ester stronger than another?
We must get a bit technical now.
So we have seen that esterification temporarily disables the steroid molecule so that assimilation by the body is more evenly distributed over time.
With an 17 beta position blocking chain, binding to the androgen receptor is not possible, it can not engage in any activity in the body.
To become the active compound, the ester must first be removed (solubility explained in the previous chapter). This automatically occurs when the compound is filtered into the bloodstream.
This will restore the hydroxyl group (OH) at position 17 beta, resulting in the attachment of the appropriate steroid receptor.
So, after the absorption of the steroid ester, it is able to have an effect on skeletal muscle tissue.
You can already begin to see why considering cypionate to be stronger than enanthate is nonsense. In fact, your muscles only distinguish it as free testosterone, regardless of the ester that was used for administration of the molecule.
There are many different esters that are used with anabolic steroids but again, they all do the same thing: reduce solubility.
An ester such as Propionate for example, will slow the release of a steroid for a few days, as the slowdown will be several weeks with a decanoate ester.
Esters therefore have no effect on the trend of aromatization to estrogen or DHT (dihydrotestosterone) of a steroid nor on the overall strength of the compound.
The differences in the results and side effects that can be noted by bodybuilders who have used different versions of the same esterified steroid are only timing issues.
For example, enanthate causes problems related to estrogen more frequently than Sustanon simply because enanthate testosterone levels will have their peak and troughs much earlier (in 1 to 2 weeks for enanthate as opposed to 3 to 4 weeks for Sustanon).
Similarly testosterone suspensions are probably more conducive to rapidly develop side effects. Just because the hormone levels in the blood have their peaks very quickly with this steroid. Instead of waiting weeks to see testosterone levels increase up to their highest point, we are here, to the highest in 2 days.
Given an equal testosterone blood level, there would be no difference in the aromatization or DHT conversion between different esters. It's just the speed of the mechanism that differs.
The different esters in detail.
Now that we know what an ester is and how it works, we will examine the best known esters in alphabetical order. This will help you better control and optimize your treatment and thus achieve better results.
Chemical structure C2H4O2.
Also referred to as acetic acid. The acetate ester delays the release of a steroid for a few days. Contrary to what you may have read, acetate esters do not increase the tendency for fat removal. Again, there is no known mechanism whereby acetate burns fat.
This ester is used in the oral tablets Primobolan (metenolone acetate) or Finaplix (trenbolone acetate - "Tren A") and occasionally for testosterone.
Chemical structure C8H14O2.
The cypionate ester is very popular in the United States. Its release time is almost identical to enanthate (10-14 days). In the US, athletes generally think that cypionate is more powerful than enanthate. Yet there is very little difference between the two. The enanthate ester is actually slightly smaller than cypionate, so it releases a slightly greater (maybe a few milligrams) amount of steroid by comparison.
Chemical structure C10H20O2.
Also referred to as decanoic acid. The decanoate ester is most often used with nandrolone (as with Deca-Durabolin). It is present in virtually every corner of the world. Testosterone decanoate is also the longest-acting active ingredient in Sustanon, greatly expanding its release time. The release time with decanoate compounds is hardly less than one month. However, it was recently found that levels seem to drop significantly after two weeks. To keep blood levels more uniform, athletes should follow a weekly injection schedule.
Chemical structure C7H14O2.
This is one of the most important esters used in the manufacture of steroids, and most frequently observed with testosterone. It is also used in other compounds such as Primobolan Depot.
Enanthate will have a balanced hormone level for about 10 to 14 days.
Although in the context of medicine, enanthate compounds are often injected on a biweekly or monthly basis, athletes, meanwhile, prefer 1 or 2 injections per week to help maintain a consistent level of testosterone.
Chemical structure C6H12O2.
This ester has a somewhat shorter life than enanthate and is only used with testosterone in a "blend" as Sustanon or Omnadren.
Chemical structure C9H10O2.
The phenylpropionate ester will extend release of the active steroid for a few days longer than the propionate ester.
To maintain blood levels similar to propionate, the injections are made at least two times per week. Deca-Durabolin is the product most commonly observed with a phenylpropionate ester (nandrolone phenylpropionate - "NPP") but it is also used with testosterone in Sustanon and Omnadren.
Chemical structure C3H6O2.
Also called Carboxyethane or propionic acid. The propionate ester will slow the release of a steroid for several days.
To allow blood levels to increase fast, the propionate compounds are usually injected two to three times per week. Testosterone propionate is one of the most well-known steroids.
Chemical structure C11H22O2.
The undecanoate ester is not very common. It only seems to be used in the preparation of nandrolone (Durabolin) and oral testosterone undecanoate (Andriol). Since this ester is chemically very similar to undecylenate (only additional two hydrogen atoms), it has a similar release time (about 2-3 weeks).
There is no reason to believe that it has unique properties compared to other esters because it is used in the oral preparation Andriol.
Andriol actually works very badly for providing testosterone, reinforcing the idea that oral administration is really not the ideal use of esterified testosterone.
Chemical structure C11H20O2.
This ester is very similar to decanoate, containing one carbon atom more. its release time is also very similar (about 2-3 weeks), which extends perhaps 1 or 2 days more than decanoate.
The Undecylenate seems to be reserved exclusively for veterinary preparation Equipoise (boldenone Undecylenate), the Equipoise works great for athletes.
Again, weekly injections are most common.
Each ester thus has its particularity concerning the release of the hormone in the body. But the release time is also dependent on another factor, a technical factor: the weight of the ester.
The longer the ester the heavier it will be. In the case of testosterone enanthate for example, 250 mg esterified steroid (testosterone enanthate) equals only 180 mg free testosterone enanthate for 70mg.
You understand now, because the propionate ester is shorter, it is the ester which is the lightest.
So although the advent of esters is a valuable advance in steroids, they do not change the anabolic steroid strength.
Testosterone remains testosterone, trenbolone remains trenbolone, etc .... Some would argue that a form of ester of a particular hormone is much better than another: it is a view totally unfounded and erroneous.
You now have all the cards in hand to best design your treatments, and if any doubts still exist, do not hesitate to contact one of our consultant who will be happy to help you.
Have a nice cycle.
The Top Steroids Online team.